There are many approaches to finding your letterforms. Many designers like to do a manual sketch first, and then digitize it. Here are two ideas to get you started.
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In a script font, you need a bunch of alternative glyphs for certain positions, and the right OpenType features to trigger them when needed. Read on how to do it.
A quick and easy introduction to turning your icon set into a webfont.
Once you have drawn a couple of letters in a Multiple Master set-up, it is a good time to determine instances. Read here how.
In order to interpolate, Glyphs needs compatible drawings in all masters. Here is how to make sure your paths are ready for interpolation.